Medications

Buspirone in Cats

Buspirone (Buspar®) is a human antidepressant drug. It has been shown to be effective in a significant number of cats with elimination (urination or defecation) disorders such as inappropriate urination, especially urine marking and other behavior problems.

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Bilberry

Bilberry is an over the counter supplement given by mouth, and is used off label to treat conditions of the eyes, heart and blood vessels, diabetes, and tumors. Give as directed by your veterinarian. There are no known side effects, but information is limited. There are no known contraindications. Certain medications should be used with caution in combination with bilberry. If a negative reaction occurs, please call your veterinary office.

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Carnitine

Carnitine is an amino acid nutrient given by mouth and is used to treat dilated cardiomyopathy and other heart diseases in dogs, or to treat hepatic lipidosis (liver disease) in cats. Give as directed by your veterinarian. Side effects are uncommon but may include mild diarrhea or vomiting. Do not use the D form of carnitine, use the L (Levo-) form only. If a negative reaction occurs, please call your veterinary office.

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Chamomile

Chamomile is given by mouth or applied topically and is used off-label and over the counter to treat inflammatory skin conditions, gastrointestinal upset, and anxiety. Give as directed by your veterinarian. Side effects are uncommon if used at the proper dose, but may include vomiting, diarrhea, or skin irritation. Do not use in pets that are allergic to it or other plants in the daisy family. If a negative reaction occurs, please call your veterinary office.

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Choline

Choline is a vitamin supplement given by mouth and is used over the counter to treat neurological conditions such as seizures or cognitive dysfunction. Give as directed by your veterinarian. Side effects are uncommon but may include hyperactivity. Do not use in pets that are allergic to it. If a negative reaction occurs, please call your veterinary office.

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Coenzyme Q-10

Coenzyme Q-10 is an over the counter supplement given by mouth and is used off label to treat heart, nerve, or inflammatory conditions in dogs and cats. Give as directed by your veterinarian. Side effects are uncommon and have not been documented. Use cautiously in pregnant or nursing pets. If a negative reaction occurs, please call your veterinary office.

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Colostrum

Colostrum is given by mouth and is used over the counter to treat various immune-mediated and inflammatory conditions. Give as directed by your veterinarian. Side effects are uncommon and may include gastrointestinal upset in pets with a dairy allergy. There are no known contraindications. If a negative reaction occurs, please call your veterinary office.

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Dimethylglycine (DMG)

Dimethylglycine is given by mouth and is used off label and over the counter to enhance racing performance, as well as supplement the treatment for some cancers, diabetes, immune diseases, or cardiovascular diseases. Give as directed by your veterinarian. Side effects are uncommon and unreported. DMG should be used cautiously in pets that are pregnant, nursing, or debilitated. If a negative reaction occurs, please call your veterinary office.

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Echinacea

Echinacea is given by mouth and is used over the counter and off label to improve immune system function and reduce inflammation. Give as directed by your veterinarian. Side effects are uncommon but may include vomiting and diarrhea. Do not use in pets that are allergic to it. If a negative reaction occurs, please call your veterinary office.

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Enzymes

Enzymes are given by mouth and are used over the counter or as a prescription to treat digestion problems, pain, or inflammation. Give as directed by your veterinarian. Side effects may include vomiting, diarrhea, and allergic reactions. Do not use in pets that are allergic to the enzyme or the source of the enzyme. Use cautiously in pets with liver or kidney disease, or in pets that are pregnant or nursing. If a negative reaction occurs, please call your veterinary office.

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Ephedra

Ephedra is prescribed most often treat breathing problems and is given by mouth. Give as directed by your veterinarian. Side effects include increased heart rate, body temperature, and blood pressure, agitation, restlessness, sleeplessness, nausea, tremors, and vomiting. Do not use in pets that are allergic, pregnant, nursing, are debilitated, elderly or young, or have glaucoma, heart disease, high blood pressure, seizures, diabetes, anxiety, enlarged prostate, liver disease, kidney disease or thyroid disease. If a negative reaction occurs, please call your veterinary office.

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Eyebright

Eyebright is an over the counter supplement, given by mouth or used topically as an adjunctive treatment for infection and inflammation of the eyes, skin, or mucous membranes. Give as directed by your veterinarian. The most common side effect is a sensitivity reaction that may include redness, itching, or irritation. Do not use in pets that are allergic to it or that are pregnant, nursing, have had eye surgery, or have diabetes. If a negative reaction occurs, please call your veterinary office.

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Fish Oil

Fish oil is an over-the-counter supplement, given by mouth, that is commonly used to treat a wide variety of inflammatory conditions. Give as directed by your veterinarian. Side effects are not common but may include vomiting, diarrhea, or a fishy odor. Do not use concurrently with anticoagulant medications. If a negative reaction occurs, please call your veterinary office.

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Flaxseed Oil

Flaxseed oil is derived from flax plant seeds and contains high levels of alpha-linolenic acid (ALA), an omega-3 fatty acid, and is used to treat certain inflammatory conditions. Give as directed by your veterinarian. Side effects may include diarrhea, vomiting, delayed wound healing, or an oily coat and skin flakes. Serious side effects include persistent stomach upset, or pancreatitis. Flaxseed oil should not be used in pets that are allergic to it. If a negative reaction occurs, please call your veterinary office.

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Flower Essences

Flower essences are an over the counter supplement given by mouth or applied topically to treat stress or anxiety. Give as directed by your veterinarian. There are no known side effects. Do not use in pets that are allergic to it or that are pregnant or nursing. Flower essences should be used cautiously in debilitated pets or pets in organ failure. If a negative reaction occurs, please call your veterinary office.

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Ginger

Ginger is given by mouth and is used off label and over the counter to treat nausea, vomiting, inflammation, and other conditions. Give as directed by your veterinarian. Side effects are uncommon but might include mild stomach discomfort, diarrhea, or gas. Do not use in pets that are allergic to it or that have gallbladder disease. If a negative reaction occurs, please call your veterinary office.

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Ginkgo

Ginkgo is given by mouth and is used on and off label and over the counter to treat cognitive dysfunction, vascular problems, retinal disease, or breathing problems. Give as directed by your veterinarian. Side effects are uncommon but may include vomiting, diarrhea, or skin allergic reactions. Do not use in pets that are allergic to it, have a bleeding disorder, or are pregnant or nursing. If a negative reaction occurs, please call your veterinary office.

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Ginseng

Ginseng is given by mouth and is used off label and over the counter to treat a variety of conditions including low energy, heart problems, Addison’s disease, cognitive function, and low immune system. Give as directed by your veterinarian. Side effects are uncommon but may include diarrhea, restlessness, or increased blood pressure. Do not use in pets that are allergic to it, are pregnant or are nursing. If a negative reaction occurs, please call your veterinary office.

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Glucosamine Chondroitin Combination

Glucosamine/chondroitin combination is a nutrient supplement that is given by mouth and is used to treat osteoarthritis and feline lower urinary tract disease. Give as directed by your veterinarian. Side effects are uncommon but may include gastrointestinal upset. Do no use in pets that are allergic to it. If a negative reaction occurs, please call your veterinary office.

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Glutamine

Glutamine is given by mouth and is used off label to treat gastrointestinal and pancreatic inflammation. It can be prescription or over the counter. Give as directed by your veterinarian. Side effects are uncommon and are not well documented in pets. Use cautiously in pets that are pregnant or nursing or have severe liver disease, severe behavior disorders, or seizures. If a negative reaction occurs, please call your veterinary office.

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Medicinal Mushrooms

Medicinal mushrooms are given by mouth and are used over the counter (and under veterinary supervision) to supplement the treatment of cancer and other conditions. Give as directed by your veterinarian. Side effects may include stomach upset, diarrhea, dizziness, and skin rash. Do not use in pets that are allergic to mushrooms, and use cautiously in pets that are pregnant, nursing, or have diabetes, clotting disorders, low blood pressure, immune-mediated disorders, liver problems, or kidney disease. If a negative reaction occurs, please call your veterinary office.

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Acetylcysteine

Acetylcysteine is given by mouth, injection, or topically and is used on and off label to treat toxicities or to break up mucus. It is usually a prescription, but some forms may be found over the counter. Give as directed by your veterinarian. The most common side effect is an upset stomach. Do not use in pets that are allergic to it. If a negative reaction occurs, please call your veterinary office.

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Aminocaproic Acid

Aminocaproic acid is a medication that blocks the breakdown of blood clots, and is used to treat postoperative bleeding, especially in sighthounds. It is given by mouth in the form of a tablet or liquid, or it can be given by injection by your veterinarian in the hospital. Side effects are uncommon but can include vomiting, diarrhea, or decreased appetite when they do occur. Do not use this medication in pets that are currently experiencing clotting in the vessels, and use with caution in pets with heart, liver, or kidney disease. If a negative reaction occurs, call your veterinary office.

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Amlodipine

Amlodipine is given by mouth and is used on and off label to treat high blood pressure in cats and dogs. Common side effects include vomiting, diarrhea, lack of appetite, sleepiness, or gingival (gum) overgrowth. Do not use in pets that are allergic to it, are in shock, have aortic stenosis, or are in liver failure. If a negative reaction occurs, please call your veterinary office.

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Amoxicillin

Amoxicillin is given by mouth and is used on and off label to treat certain bacterial infections in a variety of species. Common side effects include gastrointestinal effects such as lack of appetite, vomiting, and diarrhea. Do not use in pets that are allergic to it or other penicillins, cephalosporins, or other beta-lactam antibiotics, or in rabbits, guinea pigs, chinchillas, hamsters, or other small mammals. If a negative reaction occurs, please call your veterinary office.

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Amoxicillin-Clavulanic Acid

Amoxicillin-clavulanic acid, also known as amoxicillin and clavulanate potassium, is a synthetic penicillin-type antibiotic used to treat infections caused by gram-positive and gram-negative bacteria. It is used to treat skin and soft tissue infections, and periodontal disease. Amoxicillin-clavulanic acid comes in tablet form, or may be compounded as a liquid suspension. Amoxicillin-clavulanic acid may cause stomach upset, vomiting and diarrhea. Allergic reactions are rare, but if you observe the following signs contact your veterinarian immediately: irregular breathing, rash, fever, puffiness and swelling around the face.

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Azathioprine

Azathioprine is an immune suppressing medication given by mouth or as an injection and is mainly used off label to treat immune-mediated diseases in dogs. Common side effects include gastrointestinal upset and bone marrow suppression. This medication should not be used in pets that are allergic to azathioprine or are pregnant. It should be used with caution in pets with liver or kidney disease. If a negative reaction occurs, please call your veterinary office.

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Benazepril

Benazepril is given by mouth and is used on and off label to treat heart failure, high blood pressure, chronic kidney disease, protein-losing glomerulonephropathies, and idiopathic kidney bleeding. Side effects may include vomiting, diarrhea, and lack of appetite. Do not use in pets that are allergic to it or other ACE inhibitors. If a negative reaction occurs, please call your veterinary office.

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Bethanechol Chloride

Bethanechol chloride is given by mouth or injection and is used off label to increase urinary or intestinal movement/activity. Give this medication as directed by your veterinarian. Common side effects include vomiting, diarrhea, drooling, and lack of appetite. Do not use in pets that are allergic to it, or have urinary obstruction, stomach ulcers, gastrointestinal obstructions, intestinal inflammation, or recent intestinal, stomach, or bladder surgery. If a negative reaction occurs, please call your veterinary office.

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Bismuth Compounds

Bismuth compounds are given by mouth and are used on and off label to treat diarrhea and upset stomach. Give as directed by your veterinarian. The most common side effects include discolored stools and constipation. Do not use in pets that are allergic to it or other NSAIDs, or in pets that have a stomach or intestinal ulcer. If a negative reaction occurs, please call your veterinary office.

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Captopril

Captopril is given by mouth and is used off label to treat congestive heart failure and high blood pressure. Give as directed by your veterinarian. The most common side effects include vomiting, diarrhea, or lack of appetite. Do not use in pets that are allergic to it or other ACE inhibitors. If a negative reaction occurs, please call your veterinary office.

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Carprofen

Carprofen is used on and off label and is given by mouth in the form of a tablet to treat pain and inflammation. The most common side effects include vomiting, diarrhea, and decreased appetite. Do not use this medication in pets with bleeding disorders, in pets that are allergic to it or other NSAIDs in the same class, or in pets concurrently using corticosteroids or other NSAIDs. If a negative reaction occurs, please call your veterinary office.

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Chlorambucil

Chlorambucil is given by mouth and is used off label to treat certain types of cancer and autoimmune diseases. Common side effects include fur loss and changes in hair coat, as well as gastrointestinal upset. Do not use in pets that are allergic to it or other alkylating medications, that have bone marrow disease, have an active infection, or that are pregnant or lactating. If a negative reaction occurs, please call your veterinary office.

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Chlorothiazide or Hydrochlorothiazide

Chlorothiazide/hydrochlorothiazide is given by mouth or injection and is used off label to treat nephrogenic diabetes insipidus, high blood pressure, fluid retention, and certain electrolyte imbalances. Give as directed by your veterinarian. Common side effects include electrolyte imbalances, increased need to urinate, vomiting, or diarrhea. Do not use in pets that are allergic to them or sulfa drugs, in lactating pets, or in pets that are not able to make urine. If a negative reaction occurs, please call your veterinary office.

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Chlorpheniramine Maleate

Chlorpheniramine maleate is given by mouth and is used off label to treat allergic conditions or as a mild sedative. Common side effects include sleepiness, although other side effects are possible. Do not use in pets that are allergic to it or other similar antihistamines, or pets that are undergoing allergy testing within 2 weeks. If a negative reaction occurs, please call your veterinary office.

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Cimetidine

Cimetidine is given by mouth and is used off label to treat various gastrointestinal conditions related to acid production, such as ulcers and reflux. Side effects are uncommon and have not been documented in animals. Do not use in pets that are allergic to it or other histamine2 blockers. If a negative reaction occurs, please call your veterinary office.

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Clomipramine

Clomipramine is given by mouth and is used on and off label to treat behavior disorders such as obsessive-compulsive disorders, anxiety, aggression, and urine marking. Common side effects include lack of appetite, vomiting, diarrhea, constipation, dry mouth, elevated liver enzymes, difficulty urinating, or tiredness. Do not use in pets that are allergic to it or other tricyclic antidepressants, in breeding males, in pets with a history of seizures, or concurrently with monoamine oxidase inhibitors such as amitraz flea collars. If a negative reaction occurs, please call your veterinary office.

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Clorazepate Dipotassium

Clorazepate is given by mouth and is used off label to treat epilepsy and various behavior disorders. Give as directed by your veterinarian. Common side effects include sleepiness and incoordination. Clorazepate should not be used in pets that are allergic to it or other benzodiazepines or in pets with significant liver disease. If a negative reaction occurs, please call your veterinary office.

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Cloxacillin

Cloxacillin is given by mouth and is used off label to treat certain bacterial infections, most commonly staphylococcal infections. Common side effects include gastrointestinal upset such as vomiting and diarrhea. Do not use in pets that have an allergy to penicillins or cephalosporins. If a negative reaction occurs, please call your veterinary office.

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Codeine

Codeine is given by mouth or injection and is used off label to treat mild to moderate pain, cough, and occasionally diarrhea. Give as directed by your veterinarian. Common side effects include sleepiness and constipation. Do not use in pets that are allergic to it or other opioids, in pets with inflammatory bowel disease, or in pets that have ingested a toxic substance. If a negative reaction occurs, please call your veterinary office.

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Colchicine

Colchicine is given by mouth and is used off label to primarily treat amyloidosis and Shar-Pei fever. Give as directed by your veterinarian. Side effects are not well documented and may include nausea, vomiting, diarrhea, lack of appetite, skin rash, incoordination, severe tiredness, weakness, infections, bleeding, or bruising. Do not use in pets that are allergic to it or in pets with severe kidney, gastrointestinal, or heart disease. If a negative reaction occurs, please call your veterinary office.

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Cyclophosphamide

Cyclophosphamide is given by mouth or injection and is used off label to treat various cancers such as lymphoma, leukemia, carcinoma, and sarcoma. Common side effects include hair loss and hair coat changes. Do not use in pets that are allergic to it or that cannot be sufficiently monitored during treatment, are pregnant or lactating, have urinary obstruction, infection, bone marrow dysfunction, or have had an episode of blood in the urine that is not associated with a bladder infection. If a negative reaction occurs, please call your veterinary office.

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Cyproheptadine

Cyproheptadine is given by mouth and is used off label to treat allergic skin conditions, certain toxicities, and to stimulate appetite. Give as directed by your veterinarian. Common side effects include sleepiness, increased appetite, and dry mouth. Do not use in pets that are allergic to it or pets undergoing skin allergy testing within the next two weeks. If a negative reaction occurs, please call your veterinary office.

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Dexamethasone

Dexamethasone is given on and off label, by mouth or injection, to treat various inflammatory, autoimmune, and adrenal gland conditions. It can also be used off label as a diagnostic test. Common side effects include increased drinking, urination and/or appetite, dull/dry haircoat, weight gain, pot-bellied appearance, muscle weakness, panting, vomiting, or diarrhea. Do not use in pets that are allergic to it, have systemic fungal infections, diabetes, or stomach or intestinal ulcers, or are taking NSAIDs. It should not be used in rabbits or in surgical pets. If a negative reaction occurs, please call your veterinary office.

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Dextromethorphan

Dextromethorphan is given by mouth and is used off label to treat compulsive behaviors and occasionally used to treat cough. Side effects are uncommon but may include vomiting, diarrhea, decreased appetite, sleepiness, drooling or anxiousness. Do not use in pets that are allergic to it. If a negative reaction occurs, please call your veterinary office.

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Aminophyllin-Theophyllin

Aminophyllin is used to relieve cough, wheezing, shortness of breath and troubled breathing. The medication works by relaxing the air passages of the lungs, thus increasing the amount of air flowing into the lungs.

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Antacids-Oral

Antacids are used to neutralize excess acid (decrease the amount of acid) in the stomach. Antacids can be used for inflammation of the esophagus, excessive acid in the stomach, peptic ulcer and inflammation of the stomach. In patients with kidney failure, antacids may be used to decrease the amount of phosphate in the blood.

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Cephalosporins

Cephalosporins are a group of antibiotics used to treat infections caused by gram positive and gram negative bacteria. Cephalosporins are most commonly used to treat respiratory, skeletal, urinary, skin and soft tissue infections.

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Diazepam

Diazepam is given by mouth, injection, or into the rectum and is used off label to treat anxiety, seizures, tense muscles, or decreased appetite. Give as directed by your veterinarian. Side effects include sleepiness, increased appetite, incoordination, weakness, agitation, drooling, and aggression. Do not give to cats by mouth, and do not use in pets that are allergic to it or other benzodiazepines, or in pets with severe liver disease. If a negative reaction occurs, please call your veterinary office.

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Olive Leaf

Olive leaf is given by mouth and is used over the counter and off label to treat a variety of conditions such as high blood pressure, high blood sugar, inflammation, and infections. Give as directed by your veterinarian. Side effects are uncommon but may include headache, muscle aches, or stomach upset. Olive leaf should not use in pets that are allergic to it, or in pregnant or nursing pets. If a negative reaction occurs, please call your veterinary office.

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Diethylstilbesterol

Diethylstilbestrol is given by mouth and is used off label to treat urinary incontinence. Give as directed by your veterinarian. Side effects are uncommon when using a low dose, but may include mild vaginal spotting. It should not be used in pets that are allergic to it, in females with estrogen-sensitive tumors, in pets with anemia or low white blood cell counts, or in food production animals. If a negative reaction occurs, please call your veterinary office.

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Perna

Perna is given by mouth and is used over the counter to treat inflammatory conditions such as arthritis in cats, dogs, and horses. Give as directed by your veterinarian. The most common side effects are gastrointestinal effects such as nausea and diarrhea. Do not use in pets that are allergic to it or other shellfish, or in pregnant or nursing pets. If a negative reaction occurs, please call your veterinary office.

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Difloxacin

Difloxacin is given by mouth or as an injection, and is used to treat certain bacterial infections. Side effects are uncommon but may include nausea, vomiting, lack of appetite, and diarrhea. Do not use in pets that are allergic to it, in young or growing animals or in cats. If a negative reaction occurs, please call your veterinary office.

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Probiotics

Probiotics are given by mouth and are used over the counter to treat gastrointestinal upset. Give as directed by your veterinarian. Side effects are rare but may include gas or mild discomfort. Do not use in pets that are very sick and immunocompromised, or in pets that are allergic to it. If a negative reaction occurs, please call your veterinary office.

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Digoxin

Digoxin is used off label and is given by mouth or injection to treat certain abnormal heart rhythms and certain types of congestive heart failure. Common side effects include vomiting, diarrhea, lack of appetite, weight loss, tiredness, or behavior changes. Digoxin should not be used in pets that are allergic to it, in pets that already have too much digoxin in the bloodstream, or in pets with certain arrhythmias such as ventricular fibrillation or in cats with hypertrophic cardiomyopathy. If a negative reaction occurs, please call your veterinary office.

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Diltiazem HCl

Diltiazem is given by mouth as a tablet, capsule, or compounded liquid, and is used off label to treat abnormal heart rhythms, high blood pressure, and other heart conditions. Common side effects include a slow heart rate in dogs and vomiting in cats. This medication should not be used in pets with hypersensitivity, severely low blood pressure, lung congestion, or certain abnormal heart rhythms. If a negative reaction occurs, please call your veterinary office.

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Dimenhydrinate

Dimenhydrinate is given by mouth or injection and is used off label to treat nausea and motion sickness, and occasionally itchiness. Give as directed by your veterinarian. Common side effects include sleepiness, dry mouth, and difficulty urinating. Do not use in pets that are allergic to it or similar antihistamines, that are very young, or that are undergoing antigen skin testing within the next two weeks. If a negative reaction occurs, please call your veterinary office.

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Diphenhydramine

Diphenhydramine is given by mouth or as an injection and is used on and off label to treat allergic reactions, motion sickness, and to induce sedation. Side effects include sleepiness, and less commonly dry mouth and gastrointestinal upset. Diphenhydramine should not be used in pets that are allergic to this medication and should be used cautiously in pets with glaucoma, enlarged prostate, thyroid or heart disease, or are lactating. If a negative reaction occurs, please call your veterinary office.

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Doxycycline

Doxycycline is an antibiotic given by mouth in the form of a tablet, capsule, or liquid, used off label to treat certain infections. Common side effects include stomach upset, sun sensitivity, and increases in liver enzymes. Serious side effects include liver failure, seizures, and trouble swallowing. Do not use in pregnant pets, and use cautiously in pets with liver disease or in young pets. If a negative reaction occurs, please call your veterinary office.

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Enalapril

Enalapril is used on and off label and is given by mouth or injection to treat heart failure, high blood pressure, chronic kidney disease, or proteinuria. Common side effects include loss of appetite, vomiting, diarrhea, and tiredness. Do not use in pets that are allergic to it, have an acute kidney injury, or have certain heart conditions. If a negative reaction occurs, please call your veterinary office.

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Enrofloxacin

Enrofloxacin is an antibiotic given by mouth or in the muscle commonly used to treat bacterial infections in cats, dogs, and off label in small mammals, birds, and reptiles. Common side effects include vomiting, diarrhea, and lack of appetite. It should not be used in growing or dehydrated pets, or in cats with kidney disease. Use cautiously in pets with seizures, liver, or kidney disease. If a negative reaction occurs, please call your veterinary office.

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Ephedrine

Ephedrine is most commonly given by injection (and rarely by mouth) and is used off label to treat low blood pressure and certain types of urinary incontinence. Give as directed by your veterinarian. Common side effects include restlessness, fast heartbeat, and high blood pressure. Do not use in pets that are allergic to it or in pets with severe heart disease or abnormal heart rhythms. If a negative reaction occurs, please call your veterinary office.

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Famotidine

Famotidine is an antacid given by mouth or into the vein, and is commonly used off label to treat gastrointestinal ulcers and acid reflux. Side effects are uncommon but may include a slow heart rate, stomach upset, or dry mouth and skin. Use cautiously in pets that are geriatric or have liver, kidney, or heart disease. If a negative reaction occurs, please call your veterinary office.

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Fenbendazole

Fenbendazole (brand names Panacur®, Safe-Guard®) is a medication used to treat a variety of parasites in dogs. Its use in cats for the treatment of parasites is off label or extra label. Fenbendazole comes as oral granules or as a liquid suspension and is given by mouth. Liquid forms must be measured carefully. Give this medication as directed by your veterinarian. At regular doses, fenbendazole does not usually cause any side effects. Fenbendazole should not be used in puppies younger than 6 weeks of age or in sick animals. If you suspect an overdose or an adverse reaction to the medication, call your veterinary office immediately.

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S-Adenosyl-Methionine (SAMe)

SAMe is given by mouth and is used on label and over the counter to treat liver disease and other conditions. Give as directed by your veterinarian. Side effects are uncommon but may include mild stomach upset. Antidepressants, dextromethorphan, meperidine, pentazocine, and tramadol should be used with caution when given with SAMe. Inform your veterinarian of all medications, vitamins, and supplements that your pet is taking. If a negative reaction occurs, please call your veterinary office.

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Fipronil

Fipronil is used topically to treat flea, tick, and chewing lice infestations. Side effects are uncommon, but may include skin irritation at the application site. Do not use this product on pets less than 8 weeks old, geriatric pets, or sick/weak pets. If a negative reaction occurs, please call your veterinary office.

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Slippery Elm

Slippery elm is given by mouth and is used over the counter to treat cough and stomach upset. Give as directed by your veterinarian. There are no known side effects. Do not use in pets that are allergic, pregnant, or nursing. If a negative reaction occurs, please call your veterinary office.

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Soy Protein

Soy protein is given by mouth and is used over the counter to treat many conditions such as urinary incontinence, certain cancers, inflammation, obesity, and diabetes. Side effects may include gastrointestinal signs, or allergic reactions. Do not use in pets that are allergic to it, or in pets that are pregnant or nursing. If a negative reaction occurs, please call your veterinary office.

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St. John's Wort

St. John’s wort is given by mouth and is used over the counter to treat pain, depression, anxiety, and other conditions. Give as directed by your veterinarian. The most common side effects include gastrointestinal upset, sun sensitivity, skin reactions, allergic reactions, dry mouth, or restlessness. Do not use in pets that are allergic to it, pregnant, nursing, very young, or very old or debilitated. If a negative reaction occurs, please call your veterinary office.

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Fluconazole

Fluconazole is an antifungal medication used off label in cats, dogs, and small mammals to treat fungal infections, especially those in the brain and spinal cord. It is given by mouth in the form of a tablet or liquid suspension, and is also available as an injection for hospital use. Common side effects include gastrointestinal upset such as decreased appetite, vomiting, and diarrhea but liver toxicity can also occur. It should be used with caution in pets with liver or kidney disease, or pregnant or lactating pets. If a negative reaction occurs, call your veterinary office.

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Fludrocortisone Acetate

Fludrocortisone acetate is given by mouth and is used off label to treat hypoadrenocorticism (Addison’s disease) and hyperkalemia. Give as directed by your veterinarian. Side effects are uncommon but may include vomiting. Do not use in pets that are allergic to it or in lactating pets without using a milk replacer. If a negative reaction occurs, please call your veterinary office.

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Flunixin Meglumine

Flunixin meglumine is given by mouth, injection, or applied directly to the skin and is used on and off label to treat pain and inflammation in a variety of species. Give as directed by your veterinarian. Side effects include swelling at the injection site, muscle stiffness, or sweating. Do not use in pets that are allergic to it or other NSAIDs, in pets expecting to give birth within the next 2 days, or in birds. If a negative reaction occurs, please call your veterinary office.

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Fluoxetine

Fluoxetine is given by mouth and is used on and off label to treat various behavioral conditions. Common side effects include sleepiness and decreased appetite. Do not use in pets with a history of seizures, that are on medications that lower the seizure threshold, that are allergic to it, taking MAOIs, younger than 6 months old, or aggressive pets. If a negative reaction occurs, please call your veterinary office.

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Glipizide

Glipizide is given by mouth and is used off label to treat high blood sugar in cats with mild type 2 diabetes. Give as directed by your veterinarian. Common side effects include temporary vomiting and a lack of appetite. Do not use in pets that are allergic to it or other sulfonamides, or in pets with trauma, infection, diabetic coma, low blood sugar, or diabetic ketoacidosis. If a negative reaction occurs, please call the veterinary office.

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Furosemide

Furosemide is given my mouth or injection and is used on and off label to treat many conditions including congestive heart failure and fluid retention. Common side effects include increases in urination, diarrhea, or constipation. Do not use in pets that are allergic to it or in those that are unable to make urine. If a negative reaction occurs, please call your veterinary office.

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Griseofulvin

Griseofulvin is given by mouth and is used on and off label to treat skin, hair, and nail fungal infections. Give as directed by your veterinarian. Common side effects include lack of appetite, vomiting, and diarrhea. Do not use in pets that are allergic to it, pregnant pets, breeding males, pets that have severe liver disease, or in cats with FIV or FeLV. If a negative reaction occurs, please call your veterinary office.

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Hydralazine

Hydralazine is given by mouth and is used off label to treat high blood pressure and some causes of heart failure. Side effects include decreased appetite, vomiting, and/or diarrhea. Do not use in pets that are allergic to it or in pets with heart vessel disease, low blood pressure, severe dehydration, or severe blood loss. If a negative reaction occurs, please call your veterinary office.

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Hydroxyzine

Hydroxyzine is given by mouth or injection and is used off label to treat allergic or itchy conditions. Give as directed. The most common side effect is sedation. Do not use in pets that are allergic to it or cetirizine, or pets that have heart failure, urinary obstruction, or stomach obstruction. If a negative reaction occurs, please call your veterinary office.

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Imidacloprid - Topical

Imidacloprid is used on and off label and is applied topically to the skin to treat flea infestations. It is frequently used in combination with other medications to treat a variety of parasites. Side effects are uncommon but may include irritation at the application site, or, if the medication is accidentally ingested, drooling, shaking, vomiting, and decreased appetite. Do not use combination products in young pets. Certain combination products should be used in cats. If a negative reaction occurs, please call your veterinary office.

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Imipramine

Imipramine is given by mouth or injection and is used off label to treat behavior disorders, sudden loss of muscle tone, urinary incontinence, cancer pain, and other conditions. Give as directed by your veterinarian. Common side effects include sleepiness, dry mouth, and constipation. Do not use in pets that are allergic to it or other tricyclic antidepressants, pets currently using MAOIs, or pets that are pregnant or nursing. If a negative reaction occurs, please call your veterinary office.

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Insulin

Insulin is used on and off label and injected under the skin to treat diabetes, ketoacidosis, and high potassium levels. Side effects may include low or high blood sugar levels, insulin resistance, and skin allergic reactions to the injections. Do not use in pets who are having an episode of low blood sugar levels and do not use pork insulins in pets with a pork allergy. If a negative reaction occurs, please call your veterinary office.

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Interferon Alfa

Interferon alfa is given by mouth or injection and is used off label to treat certain viral diseases in dogs and cats. Give as directed by your veterinarian. Side effects are uncommon but may include vomiting or decreased appetite. Do not use in pets that are allergic to it or that are receiving immediate vaccination. If a negative reaction occurs, please call your veterinary office.

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Itraconazole

Itraconazole is given by mouth in the form of a capsule, tablet, or liquid to treat fungal infections in cats and for off label treatment in dogs and small mammals. The most common side effects are anorexia, vomiting, liver toxicity, skin lesions, or limb and vessel swelling. It should not be used in pets with liver disease or low stomach acid production, and used with caution in pregnant, lactating, or pets with heart disease. If a negative reaction occurs, call your veterinary office.

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Ivermectin

Ivermectin is most commonly used as a heartworm preventive in dogs and cats. It also used off label for treating a variety of internal and external parasites. Ivermectin may be combined with other deworming medications. Ivermectin is available as tablets, chewable tablets, a topical liquid (for ear mite treatments), and an injectable that your veterinarian will administer. Some breeds of dogs (e.g., collies, sheepdogs, and collie- or sheepdog-cross breeds) are more sensitive to ivermectin than others. There are some medications that interact with ivermectin, so it is important to tell your veterinarian about all medications your pet is taking. If you suspect an overdose or an adverse reaction to the medication, call your veterinary office immediately.

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Kaolin/Pectin

Kaolin/pectin is given by mouth and is used off label to treat diarrhea and certain toxicities. Use as directed by your veterinarian. Side effects are uncommon, but constipation is possible (rarely). Do not use in pets that are allergic to it, or to control severe diarrhea or diarrhea that is caused by an infection. Do not use the combination product that includes bismuth subsalicylate in cats. If a negative reaction occurs, please call your veterinary office.

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Ketoconazole - Oral

Ketoconazole is an antifungal given by mouth in the form of a tablet, used off label to treat fungal infections in dogs, cats, small mammals, and reptiles. The most common side effects are vomiting, diarrhea, lack of appetite, and weight loss. Do not use in pets that are allergic to it, and use severe caution when using in cats or pregnant pets. If a negative reaction occurs, please call your veterinary office.

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Ketoprofen

Ketoprofen is given by mouth or injection and is used on and off label to treat pain and inflammation in many animal species. Give this medication as directed by your veterinarian. Common side effects include gastrointestinal upset such as vomiting, diarrhea, and lack of appetite. Do not use in pets that are allergic to it or other NSAIDS, in horses used for breeding, or in pets using other NSAIDs. If a negative reaction occurs, please call your veterinary office.

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Lactulose

Lactulose is used off label and is given by mouth to treat high blood ammonia levels and constipation. The most common side effects are diarrhea, bloating, gas, and abdominal cramping. Do not use in pets that are allergic to it or in pets with intestinal blockage/obstruction. If a negative reaction occurs, please call your veterinary office.

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Levothyroxine

Levothyroxine is thyroid hormone replacement given by mouth in the form of a tablet or capsule. It is used to treat hypothyroidism and its use in cats and certain exotic animals is off label. Side effects are rare; when given at high doses, side effects include increases in heart rate, appetite, drinking, urinating, excitability, nervousness, and panting. This medication should not be used in pets with certain heart conditions, untreated Addison’s disease, or hyperthyroidism. If a negative reaction occurs, call your veterinary office.

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Lincomycin

Lincomycin is given by mouth or injection and is used on and off label to treat certain bacterial infections. Give as directed by your veterinarian. Common side effects include vomiting, diarrhea, or drooling. Do not use in pets that are allergic to it or similar drugs, in pets with a candida fungal infection, very young pets, or in rabbits, hamsters, guinea pigs, or horses. If a negative reaction occurs, please call the veterinary office.

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Loperamide

Loperamide is given by mouth and is used off label to treat signs of diarrhea. Give as directed by your veterinarian. Common side effects include constipation, bloat, and sleepiness. Do not use in pets that are allergic to it, that have diarrhea due to an infection or a toxin, or that are positive for the MDR1 gene. If a negative reaction occurs, please call your veterinary office.

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Lufenuron

Lufenuron is an FDA-approved medication given by mouth in the form of a tablet, liquid, or injection (cats only) to treat flea infestations. Side effects are uncommon but may include vomiting, diarrhea, lack of appetite, tiredness, reddening of the skin, or itchiness. Do not use in pets that are allergic to it. If a negative reaction occurs, please call your veterinary office.

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Lysine

Lysine is given by mouth and is used on and off label to treat signs and symptoms associated with feline herpes virus infection in cats. Give as directed by your veterinarian. Side effects are uncommon but may include diarrhea. There are no specific contraindications for using this supplement. If a negative reaction occurs, please call your veterinary office.

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Medroxyprogesterone Acetate

Medroxyprogesterone acetate is given by mouth or injection and is used off label to treat reproductive conditions, sexual behaviors, and certain types of dwarfism and alopecia. Give this medication as directed by your veterinarian. Common side effects include increased appetite, increased thirst, weight gain, sleepiness, or changes in personality. Do not use in pets that are allergic to it, pets with diabetes or uterine bleeding, or prior to puberty, during pregnancy, 1-2 months after a heat cycle, or to treat false-pregnancy. If a negative reaction occurs, please call your veterinary office.

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Marbofloxacin

Marbofloxacin is given by mouth and is used on and off label to treat certain bacterial infections including leishmaniasis, tuberculosis, and hemoplasmosis. Common side effects include vomiting, diarrhea, and lack of appetite. Do not use in pets that are allergic to it or other quinolones, or in small and medium breed dogs before 8 months of age, in large breed dogs before 12 months of age, in giant breed dogs before 18 months of age, or in cats before 12 months of age. If a negative reaction occurs, please call your veterinary office.

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Megestrol Acetate

Megestrol acetate is given by mouth in the form of a tablet or liquid and is used in dogs or off label in cats to postpone the heat cycle or to treat false pregnancy. It can also be used off label in male dogs to treat prostatic hypertrophy. Common side effects include increased appetite, weight gain, lethargy, and behavior changes, but more severe side effects are also possible. It should not be used in pregnant pets or pets with uterine disease, diabetes, or breast tumors. If a negative reaction occurs, please call your veterinary office.

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Methimazole

Methimazole is an antithyroid medication used to treat hyperthyroidism. It is either given by mouth or applied topically to the skin. Common side effects include vomiting, anorexia, and tiredness, but more severe side effects are possible. It is contraindicated in pregnant or nursing pets, as well as in cats with autoimmune disease, liver or kidney disease, and/or blood and clotting diseases. If a negative reaction occurs, call your veterinary office.

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Methocarbamol

Methocarbamol is given by mouth or injection and is used on and off label to treat muscle spasms due to injury, inflammation, or certain toxicities. Give as directed by your veterinarian. The most common side effect includes sleepiness. Do not use methocarbamol in pets that are allergic to it. If a negative reaction occurs, please call your veterinary office.

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Methylprednisolone

Methylprednisolone is given by mouth or injection and is used on and off label to treat inflammatory, immune-mediated, or hormonal conditions. Common side effects include increased drinking, urination, and appetite, dull/dry haircoat, and/or weight gain. Do not use in pets that are allergic to it, receiving NSAIDs, that are recovering from a recent surgery, or in pets with systemic fungal or viral infections, diabetes, Cushing’s disease, stomach or intestinal ulcers. If a negative reaction occurs, please call your veterinary office.

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Metoclopramide

Metoclopramide is given by mouth or injection and is used off-label to treat gastrointestinal motility disorders, nausea, and vomiting in dogs, cats, and other animals. Give as directed. Side effects are uncommon but may include restlessness, hyperactivity, muscle twitches, drowsiness, and increased urination. Do not use in pets with intestinal blockage or bleeding, pseudopregnancy, pheochromocytoma, or a history of seizures or head trauma. If a negative reaction occurs, contact your veterinarian.

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Metronidazole

Metronidazole is given by mouth or injection and is used off-label to treat certain anaerobic bacterial and protozoal infections and gastrointestinal conditions in dogs, cats, and other animals. Give as directed. Side effects may include nausea, vomiting, diarrhea, regurgitation, decreased appetite, tiredness, and drooling. Do not use in pets that are allergic to it, are debilitated, or are pregnant or nursing. If a negative reaction occurs, contact your veterinarian.

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Milbemycin Oxime

Milbemycin oxime is a heartworm disease preventive and treats internal parasites (e.g., hookworms and roundworms) in dogs and cats. It is also found in combination products with other drugs. It is also used off label to treat infestations in dogs. Milbemycin is given by mouth with a flavored oral tablet. At regular doses, milbemycin is well-tolerated; when used at higher doses for treating mites, side effects have been observed. Some breeds of dogs (e.g., collies, sheepdogs, and collie- or sheepdog-cross breeds) are more sensitive to milbemycin than others; your veterinarian will advise you on the safety of milbemycin use in your dog. If you suspect an overdose or an adverse reaction to the medication, call your veterinary office immediately.

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Misoprostol

Misoprostol is used to treat or prevent stomach ulcers, especially when they may be caused or aggravated by non-steroidal anti-inflammatory medications. Misoprostol helps the stomach protect itself against acid damage. It also decreases the amount of gastric acid produced by the stomach. This medication may be used for other conditions as determined by your veterinarian.

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Mitotane

Mitotane is primarily used to treat Cushing's disease in dogs. It has also been used to treat adrenal gland tumors. Mitotane reduces the amount of cortisone-like hormones produced by the adrenal cortex. These steroids are important for various body functions; however excessive levels of these hormones can cause problems.

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Nitenpyram

Nitenpyram is given by mouth and is used on and off label to treat adult flea infestations and fly larvae infestations. Give as directed by your veterinarian. The most common side effect is itchiness. Do not use in pets that are allergic to it, in pets that weigh less than 2 pounds, or in pets younger than 4 weeks old. If a negative reaction occurs, please call your veterinary office.

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Nystatin - Oral

Nystatin is an antifungal, given by mouth in the form of a tablet or liquid suspension, and used off label to treat Candida fungal infections in dogs, cats, birds, and reptiles. Side effects are rare, but at high doses could cause stomach upset or mouth irritation. It should not be used in pets that are allergic to it. If a negative reaction occurs, please call your veterinary office.

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Omeprazole

Omeprazole is given by mouth and is used off-label to treat ulcers and erosions in the stomach and upper small intestine. Give as directed. Side effects are uncommon but may include stomach upset, such as vomiting, diarrhea, or gas. Do not use in pets with a history of allergies to this class of drugs. If a negative reaction occurs, call your veterinarian.

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Ondansetron

Ondansetron is given by mouth or injection and is used off label in dogs and cats to treat vomiting. Side effects are not common but include constipation, sleepiness, or head shaking. Do not use in pets that are allergic to the medication. If a negative reaction occurs, please call your veterinary office.

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Orbifloxacin

Orbifloxacin is given by mouth and is used on and off label to treat certain susceptible bacterial infections. Give as directed by your veterinarian. The most common side effects include vomiting, diarrhea, and lack of appetite. Do not use in pets that are allergic to it or other quinolones, in growing pets, or in conjunction with cyclosporine. If a negative reaction occurs, please call your veterinary office.

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Oxazepam

Oxazepam is given by mouth and is used off label to stimulate appetite and to treat behavior-related disorders. Give as directed by your veterinarian. Common side effects include sleepiness and drooling. Do not use in pets that are allergic to it or other benzodiazepines, nursing pets, or those that have glaucoma. If a negative reaction occurs, please call your veterinary office.

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Paroxetine

Paroxetine is given by mouth and is used off label to treat certain behavior disorders such as aggression, anxiety, and urine-marking. Give as directed by your veterinarian. Common side effects include sleepiness and decreased appetite. Do not use in pets that are allergic to it or other SSRIs, or pets currently taking MAOIs. If a negative reaction occurs, please call your veterinary office.

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Pentoxifylline

Pentoxifylline is given by mouth and is used off label to treat skin disorders and poor perfusion due to inflamed blood vessels. Give as directed. Common side effects include vomiting, diarrhea, lack of appetite, excitement, or restlessness. Do not use in pets that are allergic to it, allergic to xanthines, or in pets with bleeding in the brain or eye. If a negative reaction occurs, please call your veterinary office.

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Phenobarbital

Phenobarbital is used off label and given by mouth or as an injection to treat seizures or to sedate your pet. Common side effects include sleepiness, increased thirst, urination, and/or appetite. Do not use this medication in pets with liver, lung, or kidney disease or those that are allergic to barbiturates. If a negative reaction occurs, please call your veterinary office.

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Phenoxybenzamine

Phenoxybenzamine is given by mouth and is used off label to treat urination difficulty related to sphincter tone, high blood pressure related to pheochromocytoma, and laminitis in horses. Phenoxybenzamine should be given as directed by your veterinarian. Common side effects include nausea, vomiting, diarrhea, small pupils, increased heart rate, and nasal congestion/stuffy nose. Do not use in pets that are allergic to it, in pets that cannot handle low blood pressure, or in horses with colic. If a negative reaction occurs, please call your veterinary office.

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Phenylbutazone

Phenylbutazone is given by mouth or injection and is used on and off label to treat pain and inflammation. Give as directed by your veterinarian. Serious side effects include skin sores, changes in eating/drinking, changes in urination, yellowing of the skin, gums, or eyes, swelling of the legs, weight loss, behavior change, or abnormal bleeding. Do not use in pets that are allergic to it or in pets with bone marrow disease, bleeding disorders, stomach or intestinal ulcers, or pregnancy. If a negative reaction occurs, please call your veterinary office.

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L-Carnitine

L-Carnitine is an amino acid derivative. It is synthesized from methionine and lysine. The body requires L-carnitine for energy metabolism. This medication has been used as adjunctive therapy for dogs with dilated cardiomyopathy. Other uses include protection against doxorubicin-induced cardiomyopathy and reduction of the risk of damage to the myocardium due to interruption of the blood supply to this area. L-carnitine has been used in cats as adjunctive therapy to facilitate metabolism of liver fat.

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Phenylpropanolamine

Phenylpropanolamine is given by mouth and is used on and off label to treat urinary incontinence. Give as directed by your veterinarian. The most common side effects include vomiting, diarrhea, lack of appetite, increased thirst, restlessness, irritability, and difficulty urinating. Do not use in pets that are allergic to it or are pregnant. If a negative reaction occurs, please call your veterinary office.

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Phytonadione (Vitamin K1)

Phytonadione is given by mouth and is used on and off label to treat vitamin K1 deficiencies in a variety of animal species, usually due to toxicities. Give as directed by your veterinarian. Side effects are uncommon. Do not use in pets that are allergic to it unless the benefits outweigh the risks. If a negative reaction occurs, please call your veterinary office.

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Pimobendan

Pimobendan is a medication given by mouth as a tablet or liquid, used to treat congestive heart failure in dogs. Its use in cats is off label. The most common side effects include decreased appetite and diarrhea. This medication should not be used in dogs with certain heart conditions, and it should be used with caution in pets with metabolic disease or pets that are young, pregnant, breeding, or lactating. If a negative reaction occurs, call the veterinary office.

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Piroxicam

Piroxicam is used off label and given by mouth in the form of a capsule to primarily treat transitional cell carcinoma. The most common side effects are gastrointestinal upset, and stomach ulcers. Piroxicam should not be used in pets with preexisting ulcers or bleeding disorders. Use with caution in pets pregnant, lactating, or aging pets, or pets with impaired heart function. If a negative reaction occurs, please call your veterinary office.

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Bromides

Bromides are given by mouth and are used off label to treat seizures in dogs. Common side effects include sleepiness, mild vomiting, restlessness, increased or decreased appetite, constipation, increased thirst, and increased urination. Do not use bromides in cats or in pets that are allergic to it. If a negative reaction occurs, please call your veterinary office.

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Potassium Salts

Potassium salts are given by mouth or an injection and are used on and off label to treat low blood potassium levels. Common side effects include nausea or discomfort. Do not use in pets that have high potassium levels, urination problems, tissue damage, uncontrolled Addison’s disease, gastrointestinal movement problems, or dehydration. If a negative reaction occurs, please call your veterinary office.

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Praziquantel

Praziquantel is given on and off label and by mouth or injection to treat various internal parasites. Side effects are uncommon but may include lack of appetite, vomiting, diarrhea, drooling, or tiredness. Do not use in pets that are allergic to it, in puppies less than 3 weeks old, or kittens less than 6 weeks old. If a negative reaction occurs, please call your veterinary office.

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Prednisolone/Prednisone

Prednisone/prednisolone is given by mouth or injection and is used on and off label to treat Addison’s disease, inflammatory conditions, neoplasia (cancer), and immune-mediated diseases. Give this medication as directed by your veterinarian. Common side effects include increased drinking, increased urination, and increased appetite. Do not use in pets that are allergic to it, or pets with systemic fungal infections, viral infections, ulcers, tuberculosis, or Cushing’s disease. If a negative reaction occurs, please call your veterinary office.

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Procainamide

Procainamide is used off label and given by mouth or injection to treat abnormal heart rhythms. Side effects may include loss of appetite, vomiting, diarrhea, weakness, low blood pressure, less effective heart beats, and rhythm abnormalities. Do not use in Doberman Pinchers, Boxers, pets that are allergic to it or related drugs, or pets with myasthenia gravis, torsade de pointes, cardiac glycoside intoxication, or heart block. If a negative reaction occurs, please call your veterinary office.

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Meloxicam

Meloxicam is a non-steroidal anti-inflammatory drug (NSAID) used to relieve pain, inflammation, and fever in dogs and cats. It is indicated for the treatment of osteoarthritis in dogs and cats. Meloxicam is also used to treat pain associated with surgery. Annual blood testing before and after starting the use of meloxicam is recommended to monitor liver and kidney function primarily or to detect other signs consistent with gastrointestinal ulceration. It is common for your veterinarian to recommend or require annual blood tests to assess for effects on organ function.

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Neomycin Sulfate

Neomycin sulfate is an antibiotic. It is used to reduce the number of bacteria in the colon (a part of the intestine) prior to surgery. It may also be used to decrease the numbers of ammonia producing bacteria in the treatment of brain disorders caused by the liver not working properly (a condition called hepatic encephalopathy).

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Penicillins - General

Penicillin antibiotics are effective against a range of infections caused by gram positive and gram negative bacteria. This medication has been prescribed for your pet to treat a bacterial infection.

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Propantheline Bromide

Propantheline bromide is given by mouth or injection and is used off label to treat diarrhea, slow heart rate, and incontinence. Give as directed by your veterinarian. Common side effects include dry mouth, dry eyes, fast heart rate, difficulty urinating, and constipation. Do not use in pets that are allergic to it or similar drugs, or pets that have certain heart, bladder, or intestinal problems, glaucoma, or myasthenia gravis. If a negative reaction occurs, please call your veterinary office.

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Propranolol

Propranolol is given by mouth or injection and is used off-label to treat abnormal heart rhythms. Side effects are not common but may include lack of energy and diarrhea. Do not use in pets that are allergic to it or pets with heart block, heart failure, asthma, or a slow heart rate. If a negative reaction occurs, please call your veterinary office.

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Pyridostigmine Bromide

Pyridostigmine bromide is given by mouth or injection and is used off label to treat symptoms related to myasthenia gravis. Give as directed. Dose-related side effects include drooling, diarrhea, increased urination, abdominal pain, muscle cramps, and increased tear production. Do not use in pets that are allergic to it or other bromides, or in pets that have urinary or gastrointestinal tract obstructions or blockages. If a negative reaction occurs, please call your veterinary office.

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Pyrantel Pamoate

Pyrantel pamoate is given by mouth and is used on and off label to treat intestinal parasites in many species. Give as directed. Side effects are uncommon but may include stomach upset, such as vomiting or diarrhea. Do not use in pets that are allergic to it. If a negative reaction occurs, call your veterinarian.

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Ranitidine

Ranitidine (brand name Zantac®) is used to treat gastrointestinal conditions in cats and dogs for the treatment and prevention of ulcers occurring in the stomach and small intestine. It may also be used to stimulate bowel activity in cats and rabbits. Its use in veterinary medicine is off label or extra-label. There are very few reported side effects of ranitidine. It is available over the counter, but should never be given without the guidance of your veterinarian. Some commonly prescribed medications can interact with ranitidine so it is important to tell your veterinarian about any medications that your pet is taking.

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Rifampin

Rifampin is commonly used off label to treat infections in horses, and occasionally in dogs and cats. It is usually given by mouth in the form of a capsule or compounded liquid. The most common side effects are vomiting, diarrhea, or reduced appetite. Liver dysfunction is also possible. Use with caution in pets that have pre-existing liver disease, are pregnant, are elderly, or are lactating. If a negative reaction occurs, please call your veterinary office.

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Selamectin

Selemectin is used topically on the skin to treat various parasites, both on and off label. Side effects are rare but may include hair loss at application site, gastrointestinal upset, skin reactions, or neurologic signs. Use with caution in sick or underweight pets, or dogs with the MDR1 mutation. If a negative reaction occurs, please call your veterinary office.

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Selegiline

Selegiline is typically given by mouth and is used off and on label to treat signs due to cognitive dysfunction syndrome, pituitary dependent Cushing’s disease, anxiety and certain phobias. Side effects may include vomiting, diarrhea, drooling, lack of appetite, and behavioral changes. Do not use in pets that are allergic to it, are aggressive, or in pets receiving other MAOIs, including certain tick collars. If a negative reaction occurs, please call your veterinary office.

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Stanozolol

Stanozolol is given by mouth and is used off label to treat poor appetite, anemia, tracheal collapse, and other conditions. Give as directed by your veterinarian. Side effects may include behavior changes, limb swelling, or prevention of heat cycles. Do not use in pets that are allergic to it, are pregnant, breeding, or nursing. Pregnant women should NOT handle this medication. If a negative reaction occurs, please call your veterinary office.

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Sulfasalazine

Sulfasalazine is given by mouth and is used off label to treat inflammatory large bowel disease and vasculitis. Give as directed by your veterinarian. Side effects include dry eye, decreased appetite, vomiting, yellowing of the skin, eyes, or body fluids. Do not use in pets that are allergic to it or other sulfonamides or salicylates, or in Doberman Pinschers, Miniature Schnauzers, or Samoyeds, or in pets with dry eye/KCS, intestinal or urinary blockages, or severe dehydration. If a negative reaction occurs, please call your veterinary office.

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Sulfamethoxazole/Trimethoprim

Sulfamethoxazole/trimethoprim is given by mouth in the form of a liquid suspension or is given by injection in the hospital, and it is commonly used to treat bacterial and parasitic infections, sometimes off label, in dogs, cats, small mammals, and other exotics. Common side effects include a decreased appetite, vomiting, and diarrhea, although more serious side effects are possible such as dry eye, or liver, blood, or urinary problems. Do not use in pets that have severe liver damage, blood cell problems, dehydration, or sulfa allergies. If a negative reaction occurs, please call your veterinary office.

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Sucralfate

Sucralfate (brand names Carafate® and Sulcrate®) is used to treat ulcers in cats and dogs. It is used off label or extra label. Side effects to sucralfate are not common, but can include constipation or vomiting. Other drugs may interact with sucralfate because it may impair the absorption of the medications. If blood is visible in stool or vomit it could indicate that the ulcers are getting worse. If blood is observed, contact your veterinarian.

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Taurine

Taurine is given by mouth in the form of a capsule, tablet, powder, or liquid and is used as an over the counter nutritional supplement to treat taurine deficiency, dilated cardiomyopathy, and prevent retinal degeneration. Give as directed by your veterinarian. Side effects are rare but may include vomiting. There are no known contraindications to using this supplement. If a negative reaction occurs, please call your veterinary office.

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Tetracycline

Tetracycline is given by mouth and is used off label to treat bacterial infections and inflammatory skin conditions in many animal species. The most common side effects include nausea, vomiting, diarrhea, and lack of appetite. Do not use in pets that are allergic to it or other tetracycline antibiotics, or in pregnant animals, especially in the first half of pregnancy. If a negative reaction occurs, please call your veterinary office.

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Triamcinolone Acetonide

Triamcinolone acetonide is given by mouth or injection and is used on and off label to treat Addison’s disease, inflammatory conditions, and immune-mediated diseases. Give as directed. Common side effects include increased drinking, increased urination, and increased appetite. Do not use in pets that are allergic to it, or pets with systemic fungal infections, viral infections, ulcers, tuberculosis, or Cushing’s disease. If a negative reaction occurs, please call your veterinary office.

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Trimeprazine Tartrate with Prednisolone

Trimeprazine tartrate and prednisolone combination is given by mouth and is used on and off label to treat itchiness and cough in cats and dogs. Give as directed. Common side effects include sleepiness, increased drinking, urination, and/or appetite, muscle tremors or stiffness, restlessness, and panting. Do not use in pets that are allergic to it, are undergoing allergy testing within the next month, or have untreated Cushing’s disease or gastrointestinal ulcers. If a negative reaction occurs, please call your veterinary office.

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Tylosin

Tylosin is an antibiotic given by mouth or by injection in small mammals, and is used off label to treat diarrhea and inflammatory bowel disease. Common side effects include decreased appetite and diarrhea. Do not use in pets that are allergic to it. If a negative reaction occurs, please call your veterinary office.

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Ursodiol

Ursodiol is given by mouth and is used off label to treat gallbladder and biliary liver diseases. Give as directed by your veterinarian. Side effects are uncommon, but may include diarrhea and mild discomfort. Do not use in pets that are allergic to it or other bile acid products, or in rabbits, guinea pigs, or rodents. If a negative reaction occurs, please call your veterinary office.

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Amantadine

Amantadine is an antiviral medication given by mouth in the form of a tablet, capsule, or liquid, that is mainly used off label for its pain control effects in pets. Common side effects include agitation and gastrointestinal effects. It should not be used in pets that are allergic to it, or that have untreated glaucoma. It should be used with caution in pets with liver, kidney, or heart disease, or in pets with eczema or seizures. If a negative reaction occurs, please call your veterinary office.

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Calcitriol

Calcitriol is used off label and is given by mouth or injection to treat low blood calcium levels associated with low parathyroid hormone, as well as chronic kidney disease, certain cancers, and certain skin diseases. Side effects are uncommon if the dose is appropriate. Do not use in pets that are allergic to it or those with high blood calcium, vitamin D toxicity, or malabsorption syndrome. If a negative reaction occurs, please call your veterinary office.

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Buprenorphine

Buprenorphine is used on and off label and is given by mouth into the cheek or injection to treat pain or as a preanesthetic. The most common side effect is sleepiness. Do not use in pets that are allergic to it or other opioids, or in pets being treated with amitraz. If a negative reaction occurs, please call your veterinary office.

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Chlorpromazine

Chlorpromazine is given by mouth or injection and is used off label as a sedative and to treat vomiting. Common side effects include tiredness, low blood pressure, low heart rate, or a tendency to react or startle to noises. Chlorpromazine should not be used in pets that are allergic to it or in pets with low blood pressure. If a negative reaction occurs, please call your veterinary office.

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Deracoxib

Deracoxib (brand name Deramaxx®) is a nonsteroidal anti-inflammatory drug (NSAID) used in dogs after surgery to reduce the pain associated with surgery (e.g., orthopedic and dental surgeries), as well as for the treatment of osteoarthritis. Like other NSIADs, deracoxib can affect the gastrointestinal tract with side effects. Use of other NSAIDs or corticosteroids should be avoided while your dog is taking deracoxib. Your veterinarian will do periodic blood tests to check liver and kidney function if your dog is taking deracoxib for extended periods.

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White Willow Bark

White willow bark is given by mouth and is used over the counter to treat pain and inflammation in cats and dogs. Give as directed by your veterinarian. Side effects may include stomach upset and skin rash. Do not use in pets that are allergic to it or aspirin, or in pets that are pregnant, nursing, or very young. It should be used cautiously in pets with certain medical conditions. If a negative reaction occurs, please call your veterinary office.

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Ear Drops - Antibiotic

Antibiotic ear drops are generally used to treat a bacterial ear infection, also known as bacterial otitis externa. Topical preparations are available as single medications or as combinations; common antibiotic preparations include neomycin, gentamicin, polymyxin B, enrofloxacin and silver sulfadiazine. These medications may also be combined with antifungal agents and/or corticosteroids.

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Ear Drops - Antifungal

Antifungal ear drops are generally used to treat a yeast infection that is known as Malassezia pachydermatis. Topical antifungal medications include miconazole, clotrimazole, nystatin and thiabendazole. These medications may be combined with corticosteroids, which are used to decrease inflammation.

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Atropine Sulfate Ophthalmic Preparations

Atropine sulfate is used in the eye to dilate the pupil. It may also be used to control pain in the eye due to corneal and uveal disease and in treating secondary glaucoma.

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Corticosteroid Ear Drops

Corticosteroid ear drops are generally used to decrease inflammation, itching and pain. This type of medication may also be used to decrease the amount of wax production in the ear. Corticosteroid medications that are commonly found in topical ear products include hydrocortisone, flucinolone, triamcinolone, betamethasone, and dexamethasone. These medications may be combined with antimicrobials, which are used to treat infections.

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Corticosteroids Ophthalmic

Corticosteroids are used in the eye to stop inflammation. They are most commonly used to treat conjunctivitis, episcleritis, scleritis, pannus (chronic superficial keratitis), and eosinophilic keratitis of the cat. The most common corticosteroid eye preparations are prednisolone and dexamethasone.

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Desmopressin Acetate

Desmopressin is administered into the eye or is given as an injection and is used off label to treat diabetes insipidus and von Willebrand disease. Give as directed by your veterinarian. Side effects are uncommon but may include irritation upon application to the eye. Do not use in pets that are allergic to it or pets that are prone to blood clots, such as those with heart disease. If a negative reaction occurs, please call your veterinary office.

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Dorzolamide - Ophthalmic

Dorzolamide is applied to the eye and is used off label to treat glaucoma (increased eye pressures). Give as directed by your veterinarian. Common side effects include stinging sensation, eye redness, watery eyes, and light sensitivity. Do not use in pets that are allergic to it or sulfonamides. If a negative reaction occurs, please call your veterinary office.

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Diazoxide

Diazoxide is given by mouth and is used off label to treat low blood sugar associated with insulin-producing tumors of the pancreas. Give as directed by your veterinarian. Common side effects include drooling, lack of appetite, vomiting, and diarrhea. Do not use in pets that are allergic to it or thiazide diuretics, or in pets with low blood sugar due to anything other than a tumor. If a negative reaction occurs, please call your veterinary office.

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Doxepin

Doxepin is given by mouth and is used off label to treat psychogenic dermatoses such as excessive grooming and psychogenic alopecia. Give as directed. The most common side effect is sleepiness. Do not use in pets that are allergic to it or other tricyclic antidepressants, in pets currently using an MAOI or flea/tick collar, or in pets undergoing skin allergy testing within two weeks. If a negative reaction occurs, please call your veterinary office.

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Firocoxib

Firocoxib is given by mouth and is used off label to treat pain and inflammation. Common side effects include mild decreased appetite or vomiting. Do not use in pets that are allergic to it or other NSAIDs, in dogs less than 12.5 lbs (5.7 kg), or in dogs younger than 7 months old. If a negative reaction occurs, please call your veterinary office.

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Flurbiprofen Ophthalmic

Flurbiprofen is given in the eye and is used off label to treat inflammation and pain associated with cataract surgery. Give as directed. The most common side effects include temporary stinging sensation upon application and mild redness. Do not use in pets that are allergic to it or in conjunction with other topical NSAIDs or topical steroids. If a negative reaction occurs, please call your veterinary office.

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Gabapentin

Gabapentin is given off label and by mouth and is used to treat pain and seizures in cats and dogs. The most common side effects include sleepiness and incoordination. Do not use this medication in pets that are allergic to it, and use cautiously in pregnant pets or those with kidney disease. Some liquid oral formulations contain xylitol, so read the label before administering. If a negative reaction occurs, please call your veterinary office.

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Gentamicin - Ophthalmic

Gentamicin ophthalmic is used in the eye to treat bacterial infections and end stage glaucoma. Side effects may include increased redness or eye irritation. Do not use this medication if your pet is allergic to it or has a full-thickness wound to the eye. If a negative reaction occurs, please call your veterinary office.

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Hydrocodone Bitartrate

Hydrocodone is an opiate agonist given by mouth as a tablet or liquid and used off label to treat pain and dry cough in dogs. The most common side effects include sedation and constipation. Do not use this medication in pets allergic to opiates or that have ingested a toxin. Use with caution in debilitated or geriatric pets, pets with a head injury, or pets that have thyroid, heart, lung, liver, kidney, or adrenal disease. If a negative reaction occurs, please call your veterinary office.

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Idoxuridine Ophthalmic

Idoxuridine (brand name Dendrid®, Herplex®) is an antiviral topical medication used to treat viral infections of the eye, such as herpesvirus-1 in cats. Idoxuridine comes as eye drops, or can be compounded by your veterinarian into an eye ointment. Your veterinarian will provide specific instructions for your cat. Side effects of idoxuridine include eye irritation. Pregnant women should NOT handle this medication.

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Ketorolac Ophthalmic

Ketorolac is given in the eye and is used off label to treat inflammation and pain associated with cataract surgery. Give as directed by your veterinarian. The most common side effects include temporary stinging sensation upon application and mild redness. Do not use in pets that are allergic to it. If a negative reaction occurs, please call your veterinary office.

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Latanoprost Ophthalmic

Latanoprost ophthalmic is applied in the eye and is used off label to treat elevated eye pressures and glaucoma. Give as directed by your veterinarian. Side effects include a burning or stinging sensation, mild eye redness, growth of eyelashes, or color change of the iris or around the eye. Do not use in pets that are allergic to it, or with eye inflammation (uveitis). If a negative reaction occurs, please call your veterinary office.

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Insulin Glargine

Insulin glargine is a long-acting insulin used in cats with diabetes mellitus to help regulate blood sugar.

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Levetiracetam

Levetiracetam is given by mouth or injection and is used off label to treat seizures and epilepsy. Give as directed by your veterinarian. Common side effects include sleepiness and incoordination in dogs and decreased appetite, incoordination, drooling, and sleepiness in cats. Do not use levetiracetam in pets that are allergic to it. If a negative reaction occurs, please call your veterinary office.

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Lomustine

Lomustine is given by mouth and is used off label to treat certain cancers such as mast cell tumors and brain tumors. Give this medication as directed by your veterinarian. Common side effects include vomiting, diarrhea, lack of appetite, and hair loss. Do not use in pets that are severely allergic to it. If a negative reaction occurs, please call your veterinary office.

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Niacinamide

Niacinamide is given by mouth and is used off label to treat inflammatory skin conditions in conjunction with other medications. Give as directed by your veterinarian. The most common side effects include lack of appetite, vomiting, diarrhea, and sleepiness. Do not use in pets that are allergic to it or that are undergoing skin allergy testing within the next two weeks. If a negative reaction occurs, please call your veterinary office.

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Pancrelipase

Pancrelipase is given by mouth and is used on and off label to treat exocrine pancreatic enzyme deficiency in dogs, cats, and birds. It is also used to treat fur balls in rabbits. Give as directed by your veterinarian. Common side effects at higher doses include diarrhea, cramping, gas, or vomiting. Do not use in pets that are allergic to pork. If a negative reaction occurs, please call your veterinary office.

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Polysulfated Glycosaminoglycan

Polysulfated glycosaminoglycan (PSGAG) is given by injection and is used on and off label to treat arthritis and degenerative joint disease. Side effects are uncommon but may include joint pain, joint swelling, vomiting, diarrhea, lack of appetite, or sleepiness. Do not use in pets that are allergic to it, or pets with a known or suspected bleeding disorder. If a negative reaction occurs, please call your veterinary office.

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Sotalol

Sotalol is given by mouth or injection and is used off label in dogs and cats to treat abnormal heart rhythms. The most common side effect is tiredness. Do not use in pets that are allergic to it or that have asthma, heart block, slow heart rate, uncontrolled congestive heart failure, or shock. If a negative reaction occurs, please call your veterinary office.

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Ronidazole

Ronidazole is given by mouth and is used off label to treat Tritrichomonas foetus, trichomonas, and giardia in dogs, cats, and birds. It should not be used in farmed animals. Common side effects include vomiting and decreased appetite. Do not use in pets that are allergic to it or other nitroimidazoles such as metronidazole. If a negative reaction occurs, please call your veterinary office.

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Spironolactone

Spironolactone is given by mouth and is used off label to treat congestive heart failure, fluid accumulation, and other cardiovascular problems. Common side effects include increased drinking and urinating, mild decreases in energy, mild electrolyte imbalances, or vomiting/diarrhea. Do not use in pets that are allergic to it, have elevated potassium levels, Addison’s disease, acute kidney failure, significant kidney disease, that are not urinating or that may be used for breeding. If a negative reaction occurs, please call your veterinary office.

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Tacrolimus Ophthalmic

Tacrolimus ophthalmic is applied to the eye and is used off label to treat KCS (dry eye) and other immune-mediated and inflammatory conditions of the eye. Give as directed. Side effects are not common but may include irritation, eyelid twitches, or hair loss around the eye. Do not use in pets that are allergic to it or have a viral or fungal infection in the eye. If a negative reaction occurs, please call your veterinary office.

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Tramadol

Tramadol is a synthetic opioid given by mouth in the form of a tablet, capsule, or compounded liquid, and is used off label to treat pain. Common side effects include sedation, gastrointestinal upset, or agitation. It should not be used in pets that are hypersensitive to opioids, and should be used cautiously in geriatric, sick, or pets with seizures. If a negative reaction occurs, please call your veterinary office.

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Trifluridine Ophthalmic

Trifluridine (brand names Viroptic®) is an antiviral topical medication used to treat viral infections of the eye, such as herpesvirus-1 in cats. Trifluridine comes as eye drops, or can be compounded by your veterinarian into an eye ointment. Side effects of trifluridine include eye irritation. The irritation caused by the administration of the drug may be more intense than the inflammation caused by the herpesvirus. Pregnant women should NOT handle this medication.

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Tropicamide - Ophthalmic

Tropicamide is applied in the eye and is used off label to dilate the eye and to prevent and treat scarring after cataract surgery. Give as directed by your veterinarian. Common side effects include drooling, eye dryness, temporary stinging sensation upon initial application to the eye, light sensitivity, and blurry vision. Do not use in pets that are allergic to it or that have glaucoma. If a negative reaction occurs, please call your veterinary office.

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Neomycin Bacitracin Polymyxin Ophthalmic

This triple antibiotic solution or ointment is used to treat surface bacterial infections of the eye. These infections may occur in the cornea (clear part of eye) or in the conjunctiva (pink parts around eyelids).

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Aluminum Hydroxide

Aluminum hydroxide is commonly used off label to treat high phosphate levels in pets with kidney disease. It is given by mouth, with meals, in the form of a liquid gel, powder, or a compounded capsule. The most common side effect is constipation, and therefore should be used in caution with pets with a gastrointestinal obstruction or pets prone to constipation. If a negative reaction occurs, please call your veterinary office.

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Maropitant Citrate

Maropitant citrate is given by mouth in the form of a tablet or injected under the skin and used to treat nausea and vomiting. Common side effects include vomiting and increased salivation, or pain at the injection site. It is contraindicated in pets with a GI obstruction, GI toxicity, or in pets under 8 weeks old. Use caution in pets with heart or liver disease, or in pets under 16 weeks old. If a negative reaction occurs, please call your veterinary office.

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Joint Support and Disease-Modifying Osteoarthritis Drugs (DMOADs) in Cats

This handout outlines the use of disease-modifying osteoarthritis drugs (DMOADs) in cats, specifically the use of polysulfated glycosaminoglycans (PSGAGs). The rationale for their use, potential side effects, and treatment expectations are explained.

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Azodyl

Azodyl® is a nutritional supplement that may decrease azotemia, a condition in which there is too much nitrogen (in the form of urea, creatinine, and other waste products) in the blood. Azotemia occurs in both dogs and cats that have chronic kidney disease (CKD). In theory, Azodyl® works by adding nitrogen-consuming bacteria into the intestines. Azodyl® should be considered an adjunct (secondary) treatment for CKD.

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Chemotherapy Drug Poisoning in Dogs and Cats

Chemotherapy drugs are used to treat cancer and other conditions in people because they target and kill rapidly dividing neoplastic (cancer) cells and other cells. They are primarily used as anti-cancer agents but may also provide benefits for a variety of auto-immune disorders and organ transplant recipients as immunosuppressive agents.

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Oclacitinib

Oclacitinib is given by mouth and is used to treat allergic dermatitis in dogs and has also been used off-label to treat other types of skin conditions. Give as directed. Side effects are uncommon but may include stomach upset such as vomiting, diarrhea, or decreased appetite. Do not use in pets with severe infections or in pets younger than 12 months old. If a negative reaction occurs, please call the veterinary office.

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Robenacoxib

Robenacoxib is a nonsteroidal anti-inflammatory drug used to treat pain and inflammation in dogs and cats. This drug is often used before and after surgical procedures because robenacoxib targets inflamed tissues. While most pets do well with robenacoxib, pets that are hypersensitive to it or other NSAIDs could have side effects including anorexia (lack of appetite), lethargy, depression, vomiting, diarrhea, kidney disease, and kidney failure. Robenacoxib should not be administered with any other NSAIDs or corticosteroids. If you suspect a negative reaction to the medication, call your veterinarian immediately.

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Cyclosporine - Oral

Cyclosporine is a medication that targets the immune system and is used to treat atopic (allergic) dermatitis in dogs and cats. Cyclosporine is given by mouth, in the form of a capsule for dogs and a liquid suspension for cats. The most common side effects of cyclosporine are gastrointestinal side effects, such as vomiting, diarrhea, and decreased appetite (anorexia). Cyclosporine should be used with caution in dogs and cats with kidney disease and/or diabetes. If you suspect an overdose or negative reaction to the medication, call your veterinary office immediately.

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Mirtazapine

Mirtazapine is a medication used mainly in cats to treat nausea, vomiting, and anorexia (appetite loss). Mirtazapine comes in pill form and is given orally (by mouth). Mirtazapine is generally well tolerated but side effects are possible. The most common side effect is drowsiness. Monitor your pet for signs of serotonin syndrome. If you suspect an overdose or a negative reaction to the medication, call your veterinary office immediately.

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Afoxolaner

Afoxolaner is used to treat and control flea and tick infestations in dogs. Sometimes afoxolaner is used for the treatment of sarcoptic mange or demodectic mange. The tablet should always be given as directed by your veterinarian. The majority of dogs have very few side effects from afoxolaner, provided it is given according to label recommendations and at the prescribed interval. If you suspect an overdose or negative reaction to the medication, call your veterinary office immediately.

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Fluralaner

Fluralaner is given by mouth or applied topically and is used to treat flea and tick infestations, and also off-label to treat certain types of mange and mites. Give as directed. Side effects are uncommon but may include stomach upset or neurologic symptoms. Do not use in pets with a history of seizures. If a negative reaction occurs, please call the veterinary office.

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Sarolaner

Sarolaner is given by mouth and is used to treat flea and tick infestations and has also been used off-label to treat certain types of mange and mites. Give as directed. Side effects are uncommon but may include stomach upset or neurologic symptoms. Do not use in pets with a history of seizures. If a negative reaction occurs, please call the veterinary office.

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Azithromycin

Azithromycin is given by mouth or injection and is used on and off-label to treat a variety of infections. Give as directed. Common side effects include stomach upset. Do not use in pets that are sensitive to macrolide antibiotics. If a negative reaction occurs, please call your veterinary office.

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Imidocarb dipropionate

Imidocarb dipropionate (brand name Imizol®) is a drug used to treat infections caused by protozoa. For example, it is used to treat the infection babesiosis in dogs. This infection is caused by the protozoa Babesia which is transferred to pets from tick bites. Your veterinarian will give this drug by injection.

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Chloramphenicol

Chloramphenicol is given by mouth or injection and is used on and off-label to treat bacterial infections. Give as directed. Common side effects include vomiting, diarrhea, and decreased appetite. Do not use in pets with blood disorders, in pediatric or geriatric animals, or in pregnant or nursing females. If a negative reaction occurs, please call your veterinarian.

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Finasteride

Finasteride is a medication used in dogs to restore infertility issues caused by benign prostatic hypertrophy (an enlargement of the prostate gland caused by hormones) and treat the general clinical signs associated with it. Finasteride comes in pill form and is given orally (by mouth). It may be given with or without food. This short-acting medication should stop working within 24 hours, although effects can be longer in pets with liver or kidney disease. If you suspect an overdose or an adverse reaction to the medication, call your veterinary office immediately.

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Atovaquone

Atovaquone is given by mouth and is used off-label to treat protozoal infections. Give as directed. Side effects are uncommon but may include stomach upset or skin rash. Do not use in pets that are pregnant. If a negative reaction occurs, contact your veterinarian as soon as possible.

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Allopurinol

Allopurinol (brand names Lopurin®, Zyloprim®) is a drug used to prevent the recurrence of uric acid and calcium oxalate uroliths (stones) in dogs. This medication works by decreasing the production of uric acid in the body. It is also used in the treatment of leishmaniasis in dogs and cats and is usually combined with other drugs. Be sure to tell your veterinarian about any medications (including vitamins, supplements, or herbal therapies) that your pet is taking.

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Famciclovir

Famciclovir is given by mouth and is used off-label to control feline herpesvirus. Give as directed. Side effects may include vomiting, diarrhea, decreased appetite, and increased drinking and urination. Do not use it in pets that are allergic to it or penciclovir. If a negative reaction occurs, call your veterinary office.

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Cefpodoxime

Cefpodoxime is a third-generation cephalosporin antibiotic used to treat skin infections in dogs. It is also used off-label in cats and to treat other types of infection. It is given orally in tablet or liquid form. Side effects are uncommon. If a negative reaction occurs, contact your veterinarian.

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Enrofloxacin Otic/Silver Sulfadiazine

Enrofloxacin otic is applied topically and is labeled to treat ear infections in dogs. It is also used off-label to treat ear infections in cats. Give as directed. Side effects are rare but may include temporary hearing loss or skin reactions. Do not use with pets allergic to quinolones or sulfonamides, with young animals, or with those with central nervous system disorders. If a negative reaction occurs, please call the veterinary office.

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Minocycline

Minocycline is given by mouth and is used off-label to treat certain bacterial infections and as a part of the heartworm treatment protocol. Give as directed. Common side effects include stomach upset, such as vomiting, decreased appetite, and diarrhea. Do not use in pets that are allergic to it or that are pregnant, nursing, or are very young. If a negative reaction occurs, call your veterinarian.

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Cetirizine

Cetirizine is given by mouth and is used off-label to treat and prevent pruritus (itching) associated with atopic dermatitis, urticaria (hives), and insect bite reactions in cats and dogs. Give as directed. Side effects are uncommon but may include vomiting and increased salivation. Do not use it in pets that are allergic to it or hydroxyzine. If a negative reaction occurs, contact your veterinarian.

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Cephalexin

Cephalexin (brand names Rilexine®, Keflex®, Vetolexin®) is an oral antibiotic that is used to treat pyoderma and other bacterial skin infections in dogs and is used off label or extra-label in cats to treat pyoderma and some other types of skin infections. It is sometimes used off label or extra-label to treat urinary tract infections in cats and dogs. Side effects to cephalexin are usually mild and rarely occur. It may cause gastrointestinal upset including lack of appetite, vomiting, and diarrhea. Do not use cephalexin in pets that have a known hypersensitivity or allergy to cephalosporins.

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Terbinafine - Oral

Terbinafine oral tablets or granules are commonly used off label to treat skin or systemic fungal infections in dogs and cats. Common side effects are primarily gastrointestinal such as vomiting, inappetence, and diarrhea, and should be used with caution in patients with liver or kidney disease. If treating with this medication long-term, your veterinarian will perform periodic blood tests to check liver function and monitor for any changes or elevations. If you suspect an overdose or an adverse reaction to the medication, call your veterinary office immediately.

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Terbinafine - Topical

Terbinafine cream or spray is occasionally used off label to treat skin fungal infections in dogs, or in a veterinary combination product to treat ear infections. When given as directed, side effects are rarely noted, but could include skin irritation. It is ineffective for treating fungal skin infections in cats. Your veterinarian may monitor your pet to be sure that the medication is working. If you suspect an overdose or an adverse reaction to the medication, call your veterinary office immediately.

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Trazodone

Trazodone oral tablets are commonly used off label to treat short-term anxieties or as an adjunctive treatment for behavioral disorders in dogs and cats. Side effects may include sedation, behavior changes, vomiting, and priapism. Patients with heart, kidney, or liver disease or closed angle glaucoma should use this medication with caution. Your veterinarian may monitor your pet to be sure that the medication is working. If you suspect an overdose or an adverse reaction to the medication, call your veterinary office immediately.

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Fluoroquinolones - Otic

Fluoroquinolone topical formulations are used to treat bacterial infections. They are used off label to treat external ear infections by topically applying the medication directly to the ear canal. Side effects may include increased redness or inflammation and should be discontinued and call your veterinarian if this occurs.

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Zonisamide

Zonisamide is an off label, oral, systemic medication used to treat seizures alone or with other anticonvulsants. Side effects include sedation, uncoordinated walking, inappetence, liver disease, urinary stones, and metabolic acidosis. It is contraindicated in patients with liver disease or in pregnant or breeding animals.

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Fluticasone Propionate

Fluticasone propionate is commonly used off label to treat asthma and other chronic tracheobronchial diseases. It is administered as an inhaled medication via an aerosol canister and a delivery device. Side effects are uncommon but include upper airway irritation or infection. This medication should not be used during an acute bronchospasm.

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Amitraz

Amitraz is a topical solution in the form of a medicated dip, spot-on treatment, or collar used to treat demodectic mange or for the prevention of flea and tick infestations. Common side effects include sedation, incoordination while walking, slow heart rate, gastrointestinal effects, skin irritation, and a temporary high blood sugar. This medication is contraindicated in very young, and used with caution in old, debilitated, diabetic, or small-breeds. While animals may exhibit signs of sedation, contact your veterinary office if your pet cannot be aroused from sleep or if the sedation lasts for more than 72 hours. Amitraz is toxic if swallowed, especially in the form of a collar, so contact your veterinary office immediately if this occurs. If they are not available, follow their directions in contacting an emergency facility.

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Moxidectin Topical

Moxidectin topical is applied to the skin and is commonly used to prevent heartworms and to treat topical and intestinal parasites. It has also been used off label to treat adult heartworms. Side effects are uncommon but may include lethargy, vomiting, uncoordinated walking, anorexia, diarrhea, and itching. It is contraindicated in sick, debilitated, or underweight animals. If you suspect an overdose or an adverse reaction to the medication, call your veterinary office immediately. If they are not available, follow their directions in contacting an emergency facility.

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Trilostane

Trilostane is a treatment for hyperadrenocorticism (Cushing’s Disease) and Alopecia X. It is given by mouth as a capsule, given with food. Common side effects include lethargy, vomiting, diarrhea, and anorexia. It is contraindicated in liver or kidney disease and pregnant animals. If an Addisonian crisis or any other negative reactions occur, call your veterinary office immediately.

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Gentamicin - Otic

Gentamicin topical formulations are used to treat bacterial infections. The ophthalmic formulation is used off label to treat external ear infections by topically applying the medication directly to the ear canal. Side effects may include increased redness or inflammation. If these effects occur, discontinue the medication and call your veterinarian. If you suspect an overdose or an adverse reaction to the medication, call your veterinary office immediately.

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Pyrimethamine

Pyrimethamine is an antiprotozoal tablet given by mouth and used off label to treat certain parasitic infections. Common side effects include vomiting, low appetite, tiredness, and low blood cell counts. Cats are more likely to have more severe side effects. It should not be used in pets allergic to the medication and should be used with caution with kidney, liver, or bone marrow disease. If a negative reaction occurs, call your veterinary office. Pregnant women should handle this medication carefully.

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Hydrocortisone Topical

Hydrocortisone topical is a medication applied to the skin that comes in many forms such as creams, ointments, shampoos and sprays, and is used to treat itchiness and inflammation. Side effects may include irritation at the application site, and with long-term use can include thin skin, skin bumps, and blackheads. Use this medication with caution in pregnant pets or in pets with skin tuberculosis. If a negative reaction occurs, call your veterinary office.

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Theophylline

Theophylline is used off label to treat cough caused by bronchoconstriction. It is given by mouth in the form of a tablet or liquid, or in hospital as an injection. The most common side effects include stomach upset and excitement. It should be used with caution in pets with abnormal heart rhythms, seizures, stomach ulcers, hyperthyroidism, kidney, liver, or heart disease, severely high blood pressure, severely low blood oxygen levels, or in young, old, or pregnant or lactating pets. If a negative reaction occurs, please call your veterinary office.

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Grapiprant

Grapiprant is given by mouth in the form of a tablet and is used in dogs to treat pain and inflammation associated with osteoarthritis. The most common side effects include vomiting, diarrhea, and decreased appetite. This medication should not be used in dogs that are allergic to it or dogs that are pregnant, lactating, breeding, have heart disease, are younger than 9 months old, or are smaller than 8 pounds. If a negative reaction occurs, please call your veterinary office.

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Meclizine

Meclizine is used off label and given by mouth in the form of a tablet to treat and prevent motion sickness and vomiting in dogs, cats, and small mammals. The most common side effect is sedation and sleepiness. Do not use in pets that are allergic to it. It should be used with caution in pets with concurrent prostate enlargement, bladder obstruction, heart failure, certain types glaucoma, or certain gastrointestinal obstructions. If a negative reaction occurs, please call your veterinary office.

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Sulfadimethoxine

Sulfadimethoxine is an antimicrobial given by mouth in the form of a tablet or liquid suspension, used primarily to treat coccidiosis. Its use for treating small mammals and reptiles is off label. Common side effects include vomiting, diarrhea, and decreased appetite. This medication should not be used in pets that are allergic to it, pregnant, lactating, or have severe liver or kidney dysfunction. If a negative reaction occurs, please call your veterinary office.

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Pilocarpine

Pilocarpine is used off label and given by mouth in food to treat neurogenic keratoconjunctivitis sicca and used topically in the eye to diagnose cranial nerve III problems. Common side effects include irritation of the eye, and more severe side effects include vomiting, diarrhea, increased salivation and urination, and cough. Do not use in pets that are allergic to it or that have secondary glaucoma. If a negative reaction occurs, please call your veterinary office.

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Sulfadiazine/Trimethoprim

Sulfadiazine/trimethoprim is given by mouth in the form of a liquid suspension or is given by injection in the hospital, and it is commonly used to treat bacterial and parasitic infections, sometimes off label, in dogs, cats, small mammals and other exotics. Common side effects include a decreased appetite, vomiting, and diarrhea, although more serious side effects are possible such as dry eye, or liver, blood, or urinary problems. Do not use in pets that have severe liver damage, blood cell problems, dehydration, or sulfa allergies. If a negative reaction occurs, please call your veterinary office.

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Imidacloprid - Oral

Imidacloprid is given by mouth to treat flea infestations in dogs only. Side effects are uncommon but may include vomiting, soft stools, decreased appetite, or difficulty walking. Do not use this medication cats, in puppies less than 10 weeks old or weighing less than 4 pounds, or in pregnant or lactating dogs. If a negative reaction occurs, please call your veterinary office.

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Decoquinate

Decoquinate is given by mouth and is used off label in dogs to prevent coccidia infections. Side effects are uncommon. Do not use in animals that are allergic to it or to treat coccidia infections (only use as a preventive). If a negative reaction occurs, please call your veterinary office.

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Enilconazole

Enilconazole is a topical wash/dip used to treat dermatophytosis (ring worm) in dogs and sometimes in cats. Side effects are uncommon as it is relatively well-tolerated, but in cats may include drooling, vomiting, lack of appetite, weight loss, muscle weakness, and elevated liver enzymes. Do not use in cats unless directed by your veterinarian. If a negative reaction occurs, please call your veterinary office.

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Clonazepam

Clonazepam is given by mouth and is used off label to treat seizures and certain behavioral disorders. Common side effects include sleepiness, incoordination, drooling, excitement, or increased appetite. Do not use in pets that are allergic to it or other benzodiazepines or in pets with significant liver disease. If a negative reaction occurs, please call your veterinary office.

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Chromium Picolinate

Chromium picolinate is given by mouth and is used off label to aid in the treatment of obesity and diabetes, mostly in cats. Side effects are uncommon, but watch for increased drinking or urination, or decreased appetite. Do not give to pets that are allergic to it. If a negative reaction occurs, please call your veterinary office.

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Clarithromycin

Clarithromycin is given by mouth and is used off label to treat certain bacterial infections in several animal species. Side effects include diarrhea, vomiting, appetite changes, stomach pain/cramps, or skin redness in cats. Do not use in pets that are allergic to it or other macrolide antibiotics, in rabbits, gerbils, guinea pigs, hamsters, or horses greater than 4 months old. If a negative reaction occurs, please call your veterinary office.

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Lorazepam

Lorazepam is given by mouth or injection and is used off label to treat behavioral disorders such as fears, phobias, and anxiety, as well as to treat seizures and to stimulate appetite in cats. Common side effects include sleepiness, muscle weakness, incoordination, increased appetite (cats), drooling, aggressive or unusual behavior, increased activity or anxiety, and vocalization. Do not use in pets that are allergic to it or other benzodiazepines, or that have severe breathing problems or liver disease. If a negative reaction occurs, please call your veterinary office.

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Methazolamide

Methazolamide is given by mouth and is used off label to treat open angle glaucoma. Common side effects include vomiting, diarrhea, lack of appetite, sleepiness, disorientation, or excitement. Do not use in pets that are allergic to it, have significant liver, kidney, or adrenal disease, have electrolyte imbalances, have severe obstructive lung disease, or have closed angle glaucoma. If a negative reaction occurs, please call your veterinary office.

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Mexiletine

Mexiletine is given by mouth and is used off label to treat abnormal heart rhythms and muscle disorders in dogs. Common side effects include stomach upset such as vomiting, trembling, or dizziness. Do not use in pets that are allergic to it. If a negative reaction occurs, please call your veterinary office.

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Hydroxyurea

Hydroxyurea is given by mouth and is used off label to treat certain cancers in cats and dogs. Common side effects include bone marrow suppression, lack of appetite, vomiting, diarrhea, mouth and stomach ulcers, loss of toenails and/or hair coat. Do not use in pets that are allergic to it, or in pregnant pets unless absolutely necessary. If a negative reaction occurs, please call your veterinary office.

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Ponazuril

Ponazuril is given by mouth and is used on and off label to treat protozoal parasites in a variety of animal species. Side effects are uncommon but may include soft stools. Do not use in pets that are allergic to it. Ponazuril should be used cautiously in pregnant or lactating pets, and dogs with/susceptible to dry eye (keratoconjunctivitis sicca/KCS). If a negative reaction occurs, please call your veterinary office.

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Sertraline

Sertraline is given by mouth and is used off label to treat behavior disorders in dogs and cats. Common side effects include tiredness, vomiting, diarrhea, lack of appetite, anxiety, irritability, sleeplessness, shaking, tremors, itchy skin, or panting. Do not use in pets that are allergic to it or other SSRIs, or pets that are using MAOIs, flea/tick collars, or cisapride. If a negative reaction occurs, please call your veterinary office.

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Erythromycin - Oral

Erythromycin is given by mouth or injection and is used off label to treat bacterial infections and gastrointestinal motility problems in many animal species. Common side effects include diarrhea, lack of appetite, and vomiting. Do not use in pets that are allergic to it, have liver disease or dysfunction, or in pets such as rabbits, gerbils, guinea pigs, or hamsters. If a negative reaction occurs, please call your veterinary office.

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Toceranib phosphate

Toceranib phosphate is given by mouth and is used on and off label to treat mast cell tumors and other cancers in cats and dogs. Common side effects include diarrhea, decreased or lack of appetite, lameness, or weight loss. Do not use in pets that are allergic to it, are breeding, pregnant, or lactating, are less than 24 months old, weigh less than 11 lbs (5 kg), or that are having or have had surgery in the past 2 weeks. If a negative reaction occurs, please call your veterinary office.

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Voriconazole

Voriconazole is given by mouth or injection and is used off label to treat fungal infections. Side effects are not well-known but may include vomiting, diarrhea, or decreased appetite. Do not use in pets that are allergic to it or in cats unless absolutely necessary. If a negative reaction occurs, please call your veterinary office.

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Mometasone Furoate Combination

Mometasone combinations are applied topically to the skin and are used on and off label to treat skin lesions. The most common side effect is inflammation at the application site. It should not be used on pets that are allergic to it, are pregnant, have tuberculosis of the skin, or in pets with a ruptured ear drum. If a negative reaction occurs, please call your veterinary office.

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Nystatin Combination - Topical

Nystatin combinations are applied topically to the skin and are used on and off label to treat skin lesions. The most common side effect is inflammation at the application site. Nystatin should not be used on pets that are allergic to it or on pets that have tuberculosis infections of the skin or a ruptured ear drum. If a negative reaction occurs, please call your veterinary office.

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Ferrous Sulfate

Ferrous sulfate is given by mouth and is used off label to treat iron-deficiency. Use as directed by your veterinarian. Common side effects include gastrointestinal upset such as discomfort, constipation, nausea, vomiting, and diarrhea. Do not use in pets that are allergic to it. If a negative reaction occurs, please call your veterinary office.

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Melatonin

Melatonin is given by mouth or as an implant under the skin and is used to treat sleep and behavior disorders, adrenal disease, and non-allergic hair loss, to suppress the heat cycle, and to improve breeding rates. Give as directed. Side effects are not common but may include sleepiness. Do not use in pets that are allergic to it. If a negative reaction occurs, please call your veterinary office.

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Folic Acid

Folic acid is given by mouth or injection and is used to treat folic acid deficiencies due to intestinal or pancreatic disease, or due to the use of certain medications. Give as directed by your veterinarian. Side effects are not common but may include stomach upset. Do not use in pets with a known sensitivity. If a negative reaction occurs, please call your veterinary office.

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Clopidogrel

Clopidogrel is given by mouth in the form of a tablet or compounded liquid and is used off label to prevent abnormal blood clots in dogs, cats, and horses. Give as directed by your veterinarian. Common side effects include vomiting, diarrhea, or lack of appetite. Do not use in pets that are allergic to it or that have bleeding problems. If a negative reaction or bleeding occurs, please call your veterinary office.

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Cefovecin

Cefovecin is given by injection and is used on and off label to treat bacterial infections in dogs and cats. It is typically given by your veterinarian in the veterinary hospital. Side effects are not common but may include sluggishness, and stomach upset. Adverse effects can occur up to two months after an injection. Do not use in pets that are allergic to it or other beta-lactam antibiotics, and do not use in herbivores. Cefovecin should be used cautiously in pets with kidney disease. If a negative reaction occurs, please call your veterinary office.

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Lokivetmab

Lokivetmab is given by injection and is used on and off label to treat itchiness in dogs. Give as directed. Side effects are uncommon but may include vomiting, diarrhea, sleepiness, lack of appetite, or pain at the injection site. Do not use in pets that are allergic to it. If a negative reaction occurs, please call the veterinary office.

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Sildenafil

Sildenafil is given by mouth or injection and is used off label to treat high blood pressure in the lungs or to treat megaesophagus. Give as directed. Side effects are uncommon but may include vomiting, diarrhea, decreased appetite, or skin redness in the groin area. Do not use in pets that are allergic to it or pets that take nitrate medications. If a negative reaction occurs, please call your veterinarian.

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Tadalafil

Tadalafil is given by mouth or injection and is used off label to treat high blood pressure in the lungs. Give as directed. Side effects may include vomiting, diarrhea, decreased appetite, or skin redness in the groin area. Do not use in pets that are allergic to it or pets that take nitrate medications. If a negative reaction occurs, please call the veterinary office.

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Deslorelin

Deslorelin is injected under the skin or into the muscle and is used on and off-label in horses, ferrets, and dogs to treat reproductive and adrenal conditions (off-label use in the U.S. is prohibited). Give as directed. Common side effects include swelling, sensitivity, redness, and warmth at the injection site. Do not use in pets that are allergic to it. If a negative reaction occurs, please call the veterinary office.  

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Leuprolide

Leuprolide is given by injection and is used off label in ferrets and birds to treat reproductive and adrenal problems. Give as directed. Side effects in ferrets may include pain at the injection site, breathing difficulties, and sleepiness. Do not use in pets that are allergic to it or other gonadotropin-releasing hormones, and do not use in pregnant or nursing pets. If a negative reaction occurs, please call the veterinary office.

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Low Molecular Weight Heparin

Low molecular weight heparin is given by injection under the skin and is used off label to treat abnormal blood clots. Give as directed. Side effects may include pain at the injection site. Do not use in pets that are allergic to any type of heparin or pork products. If a negative reaction occurs, call the veterinary office.

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Imatinib

Imatinib is given by mouth and is used off label to treat certain types of cancers in dogs and cats. Give as directed. Side effects may include nausea, vomiting, muscle pain, diarrhea, skin rash, or lack of energy. Do not use in pets that are pregnant or nursing. If a negative reaction occurs, call the veterinary office.

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Moxidectin + Fluralaner Topical

Moxidectin and fluralaner are combined in one topical treatment for use in cats. Moxidectin topical is an avermectin antiparasitic that is used to prevent heartworms and treat intestinal parasites (hookworms and roundworms). Fluralaner is used to treat and prevent fleas and also kills black-legged ticks (deer ticks). Give as directed. Side effects are uncommon but may include hair loss at the application site, itching, vomiting, diarrhea, lethargy, excessive drooling, and dry skin. Moxidectin + fluralaner should not be used in pets that are hypersensitive or allergic to it. Do not use this medication in sick, debilitated, or underweight cats. Use caution in cats with known neurologic disorders. If you suspect an overdose or an adverse reaction to the medication, call your veterinary office immediately. If they are not available, follow their directions in contacting an emergency facility.

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Moxidectin + Imidacloprid Topical

Moxidectin is an avermectin antiparasitic that is used to prevent heartworms and treat intestinal parasites. Imidacloprid treats and prevents fleas. These two drugs are combined in one topical product for use in cats, dogs, and ferrets. Use as directed. Side effects are uncommon and usually short-lived, however, if you suspect an overdose or an adverse reaction to the medication, call your veterinary office immediately.

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Prazosin

Prazosin is given by mouth and is used to reduce urinary sphincter tone to relax the bladder and allow easier urination in dogs and cats. It may also be used as a treatment for congestive heart failure, systemic hypertension, or pulmonary hypertension in dogs. Give as directed. Common side effects include lethargy, vomiting, diarrhea, nausea, and constipation. This medication should be used with caution in pets with kidney disease or other conditions that cause low blood pressure, as well as in MDR1-positive dogs. If a negative reaction occurs, contact your veterinarian.

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Clonidine

Clonidine is a medication that is used to treat behavioral disorders in dogs, particularly anxiety or phobia-related. Give as directed. Side effects are generally mild if present and include sedation, lethargy, agitation/excitation, aggression, and constipation. Monitoring blood pressure as well as heart rate and rhythm is recommended with chronic use. If you suspect an overdose or an adverse reaction to the medication, call your veterinary office immediately.

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Dexmedetomidine

Dexmedetomidine is a sedative/tranquilizer used primarily in cats and dogs as a pre-medication injection for anesthesia or for chemical restraint. It is also used orally in dogs for short-term anxiety management. The most common side effect is a low heart rate. Dexmedetomidine should not be used in patients with severe heart liver or kidney disease. It should be used cautiously in young, old, or weak animals. Consult your veterinary office immediately if you suspect a negative reaction or overdose.

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